Blar i Bergen Open Research Archive på forfatter "Rennard, Stephen I."

Viser treff 1-4 av 4

    • Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease 

      Qiu, Weiliang; Cho, Michael H.; Riley, John H.; Anderson, Wayne H.; Singh, Dave; Bakke, Per; Gulsvik, Amund; Litonjua, Augusto A.; Lomas, David A.; Crapo, James D.; Beaty, Terri H.; Celli, Bartolome R.; Rennard, Stephen I.; Tal-Singer, Ruth; Fox, Steven M.; Silverman, Edwin K.; Hersh, Craig P. (Peer reviewed; Journal article, 2011-09-16)
      Previous expression quantitative trait loci (eQTL) studies have performed genetic association studies for gene expression, but most of these studies examined lymphoblastoid cell lines from non-diseased individuals. We ...

    • A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci 

      Pillai, Sreekumar G.; Ge, Dongliang; Zhu, Guohua; Kong, Xiangyang; Shianna, Kevin V.; Need, Anna C.; Feng, Sheng; Hersh, Craig P.; Bakke, Per S.; Gulsvik, Amund; Ruppert, Andreas; Carlsen, Karin Cecilie Lødrup; Roses, Allen; Anderson, Wayne; Rennard, Stephen I.; Lomas, David A.; Silverman, Edwin K.; Goldstein, David B. (Peer reviewed; Journal article, 2009-03-20)
      There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ...

    • Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort 

      Celli, Bartolome; Locantore, Nicholas; Yates, Julie C.; Bakke, Per S.; Calverley, Peter M.A.; Crim, Courtney; Coxson, Harvey O.; Lomas, David A.; MacNee, William; Miller, Bruce E.; Mullerova, Hana; Rennard, Stephen I.; Silverman, Edwin K.; Wouters, Emiel F.; Tal-Singer, Ruth; Agusti, Alvar; Vestbo, Jørgen (Journal article; Peer reviewed, 2021)
      Rationale There are no validated measures of disease activity in COPD. Since “active” disease is expected to have worse outcomes (e.g. mortality), we explored potential markers of disease activity in patients enrolled in ...

    • Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype 

      Agustí, Alvar; Edwards, Lisa D.; Rennard, Stephen I.; MacNee, William; Tal-Singer, Ruth; Bakke, Per; ECLIPSE (Peer reviewed; Journal article, 2012-05-18)
      Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence ...